The one big problem with most creatine supplements is they become very unstable at the worst possible time – when you mix them with fluid. This unstable creatine converts into the waste product creatinine. This conversion is even more dramatic when the fluid used has a pH close to 7, about the same pH as water. The pH scale measures the acidity of liquids. In warm water creatine ethyl ester completely convert into inactive creatinine nearly instantaneously. Because other creatines break down into creatinine in the very water you’re asked to mix it with, it has been concluded that no beneficial effect can be gained from supplementing with their creatine.